Microcirculation

Question 1

Tissue metabolism can influence concentration gradients, for instance, depletion of cellular O2 leads to…

Answer 1

Increasing the gradient to promote increased rate of diffusion, maximizing A-V O2 difference by increasing O2 extraction.

Question 2

•Net Hydrostatic Pressure

Answer 2

–Difference between capillary & interstitial fluid pressures

Question 3

•Net Osmotic Pressure

Answer 3

–Difference between capillary & interstitial fluid colloid osmotic pressures (proteins)

Question 4

These factors influence net filtration pressure, in what direction?

1. Capillary BP (Pc )

Hydrostatic pressure (BP):

2. Plasma-colloid osmotic pressure (πP )Osmotic pressure (plasma proteins):
3. Interstitial fluid hydrostatic pressure (PIF )Hydrostatic pressure:
4. Interstitial fluid-colloid osmotic pressure (πIF )

Osmotic pressure (leaked proteins):

Answer 4

out

in

in (small)

out (minimal)