Module 12

Question 1

What are the 3 benefits of incretins?

Answer 1

• Are associated with better glucose management
• Are associated with improved cardiovascular outcomes
• Have appetite-reducing, weight-reducing effect

Question 2

What are the effects of semaglutide and liraglutide?

They’re the same

Answer 2

• Increases insulin, reduces blood glucose
• Slows gastric emptying
• Decreases appetite

Question 3

Why are tirzepatides associated with larger amounts of weight loss than semaglutides and liraglutides?

Answer 3

Dual agonism of GLP-1 and GIP

Question 4

How does orlistat work to promote weight loss?

Answer 4

It blocks lipase, thus dietary fat (30%) can’t be broken down and absorbed.

Question 5

List 4 negative side effects of orlistat.

Answer 5

• Can negatively impact absorption of fat-soluble vitamins
• Oily stools
• Flatulence
• Fecal incontinence

Question 6

What is Naltrexone?
How does Buproprion work?
How does the combination of these help treat obesity?

Answer 6

1. Naltrexone is a competitive antagonist for the μ-opioid receptor
2. Buproprion is an NDRI that activates POMC neurons in the
   hypothalamus
3. Modulate reward circuitry associated with food wanting

Question 7

Who are the Buproprion / Naltrexone drugs best suited for?

Answer 7

• People with dependency issues
• People with history of GI issues

Note: Not as effective at weight loss as GLP-1 agonists