Trade
Mucomyst, Acetedote
Class
Antidote
Mechanism of Action
Replenishes glutathione needed for non-toxic metabolism of acetaminophen
Indications
Acetaminophen Overdose
Contraindications
Asthma or bronchospasm history, Upper GI bleeding risk (PO)
Adverse Reactions
Bronchospasm, Anaphylaxis, N/V, Tachycardia, Flushing, URI symptoms
Dose -> Adult/Pediatric
150mg/kg over 60 minutes, then 50mg/kg over 4 hours, then 100mg/kg over 16 hours
Routes
IV, IO, PO
Special Considerations
Start within 8 hours for maximum benefit
Generic
n-acetylcystine