What is a mutation
A random change in an organisms DNA
How often do mutations occur
Continuously
Most do not alter the protein, or only alter it slightly so the function is still carried out
What increases the risk of mutation
Certain substances
Radiation
What can happen due to a mutation
They change the sequence of DNA meaning the sequence of amino acids that make up a protein can be changed. The proteins shape can be affected meaning its function can’t be carried out
What would happen if there is a mutation in an enzyme
The shape of the active site can change meaning it cannot bind to the substrate so it loses its function
What would happen if there was a mutation in a structural proteins
It would lose its strength
What is a non coding part of DNA
The part of the genome that does not provide instructions for making proteins.
They can control when genes are on and off, so variations here can affectct how genes are expressed
What are the three types of mutation
Insertions- new base is inserted in the base sequence- they can change multiple amino acids
Deletions- a random base is deleted- knock on effect and Change multiple amino acids
Substitution- one base is swapped for a difference base- only affects one amino acid