Ascomycota
Saccharomyceta
Subphylum Saccharomycotina
Class Saccharomycetes
Order Saccharomycetales
The ascomycetous yeasts
Order Saccharomycetales
Family Saccharomycetaceae
Saccharomyces cerevisiae
Candida albicans
Saccharomyces cerevisiae
Baker’s yeast or Brewer’s Yeast
First eukaryotic organism to have its genome sequenced
Easily cultivated
Vegemite and Marmite
are made from yeast- lots of nucleic acids which may cause gout
Saccharomyces cerevisiae asxual Reproduction
primarily by budding Budding can occur in haploid or diploid phase
Saccharomyces cerevisiae First Human Engineered Product
Vaccine against hepatitus B virus
Cellulases, amyloses
Interferon
Epidermal Growth Factor
Beta endorphin
Saccharomyces cerevisiae Sexual reproduction-
forms an ascus with four ascospores.
There are + and - mating
strains which are usually designated as ‘a’ and ‘ alpha.
Copulation does not involve specific copulation tubes
Candida albicans
Commonly found in people and other animals-
candidiasis- yeast infections of male and female genitalia, Thrush in mouth and throat, and diaper rash. Can also become systemic in immunocompromised individuals and may be fatal
Pseudohypha of Candida
an intermediate stage between yeast and hyphae
Fungal Antibiotics
People and other animals have cholesterol in their plasma membranes, but Candida albicans and other fungi have ergosterol
antifungal drugs that bind to ergosterol in the cell membrane which causes small ions to pass freely and also keeps infective hyphae from developing
Griseofulvin
(produced by Penicillium griseofulvum) one of the first antifungal drugs.
Flucanozole
inhibits ergosterol synthesis
Terbinafine
acts against another enzyme in ergosterol synthesis
5-fluorocytosine
inhibits nucleic acid synthesis
Caspofungin (an enchinocandin)
inhibits Beta (1,3)-glucan synthesis (which is part of the cell wall)
Killer Yeasts
Saccharomyces and Candida produce toxins.
toxins are produced by a double stranded RNA virus
Release of the toxin leaves a portion attached to the host membrane giving immunity
aggressive symbiont
Subphylum Pezizomycotina
Class EurotiomycetesOrder OnygenalesOrder Eurotiales
International Botanical Congress, July 2012
Ended the Melbourne dual nomenclature
One fungus, one name
Order Onygenales
Keratin degraders anamorph is the infective stage
Teleomorph
is a sexually reproductive form
Anamorph
is an asexually reproductive form
Holomorph
refers to all forms of a specific fungus
Order OnygenalesFamily Ajellomycetaceae
Ajellomyces dermatitidis is the teleomorph
Blastomyces dermatitidis is the anamorph
North American Blastomycosis
North American Blastomycosis
The anamorph causes North American Blastomycosis
It infects skin but can spread through the body and cause death