Week One Flashcards

Cellular and tissue biology, pain (64 cards)

1
Q

Define: Gross level

A

Organ or system level

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2
Q

Define microscopic level

A

Cellular level

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3
Q

Define etiology

A

What caused on influenced a disease

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4
Q

Define idiopathic

A

Cause of disease is unkown

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5
Q

Define latrogenic

A

Caused by an error in treatment or procedure

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6
Q

Define predisposing factors

A

Age, gender, inherited or environment factors

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7
Q

Define prophylaxis

A

Preventing the spread of disease

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8
Q

Define prevention

A

Modification of potentially harmful activities, vaccines , etc to prevent disease

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9
Q

Define subclinical state

A

Pathologic changes but no obvious manifestations

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10
Q

Define latent state

A

No symptoms or clinical signs evident infectious disease incubation period

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11
Q

Define prodromal perioid

A

Early development of disease, nonspecific or absent signs

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12
Q

Define precipitating factor

A

Condition that triggers an acute episode

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13
Q

Define morbidity

A

Disease rates within a group

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14
Q

Define mortality

A

Number of deaths resulting from the disease

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15
Q

Define epidemiology

A

Tracking the pattern or occurrence of a disease

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16
Q

Define incidence

A

Number of new cases within a given time perioid

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17
Q

Define prevelance

A

Number of new or existing cases within a given population and time perioid

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18
Q

Define epidemics

A

Higher number of expected cases of an infectious disease occur within an area

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19
Q

Define pandemic

A

Involve a higher number of infectious disease in many regions of the world

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20
Q

Define hyperplasia

A

Increased number of cells resulting in an enlarged tissue mass

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21
Q

Define metaplasia

A

Mature cell type is replaced by a different mature cell type

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22
Q

Define dysplasia

A

Cells vary in size and shape within a tissue

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23
Q

Define anaplasia

A

Lose normal structure and become undifferentiated or more “primal”

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24
Q

Define neoplasia

A

New growth, commonly called a tumor

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25
Define ischemia vs hypoxia
Ischemia: deficit of oxygen in the cells Hypoxia: reduced oxygen in the cells
26
Define pyroptosis
Results in lysis causing nearby inflammation
27
Define physical vs mechanical damage
Physical: excessive heat or cold, radiation Mechanical: pressure or tearing of tissue
28
Define exogenous and endogenous chemical toxins
Exogenous: from the environment Endogenous: inside the body
29
Prokaryotes have:
No distinct nuclei and no histones
30
Eukaryotes have:
Complex cellular organization, membrane bound organelles, well defined nucleus
31
True or false: hypoxia causes ischemia
False: ischemia is the most common cause of hypoxia
32
Where do macrophages originate?
The bone marrow
33
What is coagulative necrosis?
Accidental cell death caused by ischemia, dead cells become firm, opaque and white
34
What is somatic death?
Death of an entire person
35
What is pain threshhold?
Point at which a stimulus is perceived as pain
36
What is perceptual domiance?
Pain at one location may cause an increase in the threshold in another location
37
What is pain tolerance?
Duration of the time or intensity of pain that a person will endure before initiation of pain responses
38
What is the defined time frame for chronic pain?
At least 3-6 months
39
What is neuropathic pain?
A type of chronic pain that amplifies pain without stimulation. Described as burning, shooting, shocking or tingling. Caused by lesions or dysfunction of peripheral nerves, brain or spinal cord
40
What is allostasis?
The process in which multiple organ systems compensate to maintain homeostasis when one organ system is damaged
41
What is the term for reversible injury?
Sublethal
42
What is the term for irreversible damage?
Lethal
43
Name at least 5 of the 8 types of damage
Chemical Hypoxic Free radical Intentional Unintentional Immunological Infection Inflammatory
44
When a muscle cell atrophies it has fewer _____, ______ and ______
Endoplasmic reticulum, mitochondria and myofillaments
45
What are the mechanisms of atrophy?
Decreased protein synthesis and/or increased protein catabolism
46
What is autophagy?
"self-eating" oftentimes seen in chronic malnutrition cases
47
What is physical hypertrophy?
Normal changes and growth such as pregnancy
48
What is pathological hypertrophy?
Structural and functional changes associated with disease
49
True or false: hyperplasia can cause cellular death
True: prolonged hyperplasia can cause cellular death
50
True or false: hyperplasia and hypertrophy often occur together
True
51
What is compensatory hyperplasia?
A normal( physiological) adaptation that allows certain organs to regenerate such as the liver
52
What is hormonal hyperplasia?
Hormonal changes (almost entirely in estrogen-dependent organs) such as the uterus/mensural cycle.
53
What is pathological hyperplasia?
Abnormal proliferation of cells, often in response to excessive hormonal or growth changes
54
True of false: pathological hyperplasia can never be reversed
False: pathological hyperplasia can be reversed in certain cases, for example by correcting hormonal imbalances
55
True or false: dysplasia is always a precursor to cancer
False: while dysplasia is associated to neoplastic growths and are adjacent to cancerous cells, dysplasia does not indicate cancer or guarantee the development of cancer
56
True or false: dysplastic changes are oftentimes reversible
True: dysplastic changes can often be reversed once the stimulus is removed
57
Define metaplasia
The reversible replacement of one mature cell type by another
58
Give an example of metaplasia
Smoking causing bronchia metaplasia (where columnar ciliated epithelial cells are replaces by stratified squamous epithelial which do not secrete mucous or have cilia)
59
Atrophy, hypertrophy, hyperplasia and metaplasia are all examples of what?
Adaptation
60
What are signs of reversible injury?
Loss of ATP, cellular swelling, detachment of ribosomes, autophagy of lysosomes
61
What are signs of irreversible injury?
“Point-of-no-return” structurally when severe vacuolization of mitochondria occurs and Ca++ moves into cell
62
Define necrosis
Type of cellular death with severe cell swelling and breakdown of organelles
63
What is apoptosis?
Intentional/programmed cellular death
64