Adaptime immunity

Question 1

overview of B-cells

Answer 1

1. in bone marrow
   
   1. hemopoietic cells make common lymphoid progenitor cell
   2. becomes Developing B cell, leaves bone marrow
2. Mature/naive B cell goes into blood and cruises around checking out all the lymph nodes looking for its perfect mate.
3. finds its perfect mate and can become memory cell or plasma cell
   
   1. plasma cell creates antibodies

Question 2

overview of T cell

Answer 2

1. hemopoietic cell becomes common lymphoid progenitor cell which leaves and goes to thymus
2. matures in thymus
3. goes to lymph where they encounter antigens
4. can either become memory cell, helper T cell, or cytotoxic T cell

Question 3

antigen

Answer 3

a toxin or foreign substance that initiates an immune response

Must be large, complex, and biologically relevent

think: protein

Question 4

epitope

Answer 4

sequence of amino acids that our immune system is going to bind to on the antigen

extremely specific

Question 5

parts of the antibody

Answer 5

• variable
  
  • antigen binding sites
  • light chain
• constant
  
  • heavy chain

Question 6

MHC class 1

Answer 6

• “presents” a piece of OUR protein. (endogenous)
• genes
  
  • HLA-A
  • HLA-B
  • HLA-C
• found on all nucleated cells and platelets
• reacts with CD8 (cytotoxic killer) cells

Question 7

MHC class 2

Answer 7

• “presents” a piece of protein from something the cell has phagocytosed.
• genes:
  
  • HLA-DR
  • HLA-DP
  • HLA-DQ
• found on B cells, APC (antigen presenting cells)
• reacts with CD4 (helper T cells)

Question 8

CD8

Answer 8

cytotoxic T cells

Question 9

CD4

Answer 9

T Helper cells