Adenosine

Question 1

What is adenosine most used in?

Answer 1

supraventricular tachycardia (SVT)

Question 2

What enhances adenosine effects?

Answer 2

dipyridamole (antiplatelet)

Question 3

What blocks the effects of adenosine?

Answer 3

theophyllines

Question 4

What patients should adenosine be avoided in?

Answer 4

asthmatics

Question 5

What does adenosine cause in the AV node?

Answer 5

transient heart block

Question 6

What receptor is adenosine an agonist of?

Answer 6

A1 receptor

Question 7

What happens when adenosine acts on the A1 receptor in the AV node?

Answer 7

1. inhibits adenylyl cyclase
2. reduces cAMP & causing hyperpolarisation by increasing outward K+ influx

Question 8

What should adenosine be infused with?

Answer 8

large-calibre cannula

Question 9

What are the adverse effects of adenosine?

Answer 9

• chest pain
• bronchospasm
• transient flushing
• enhance conduction down accessory pathway (inc. ventricular rate)