Nitrates

Question 1

What type of drugs are nitrates?

Answer 1

vasodilators

Question 2

What is it used in the management of?

Answer 2

• angina
• acute HF

Question 3

What is the mechanism of action of nitrate?

Answer 3

release of nitric oxide in smooth muscle, activating guanylate cyclase converts GTP to cGMP resulting in a fall in Ca2+ levels

Question 4

What is the mechanism of action of nitrates in angina?

Answer 4

coronary arteries dilate and reduced venous return -> reduces LV work -> reducing myocardial oxygen demand

Question 5

What are the side effects of nitrates?

Answer 5

• hypotension
• tachycardia
• headaches
• flushing