Amiodarone

Question 1

What class of agent is amiodarone?

Answer 1

class III antiarrhythmic agent

Question 2

What is amiodarone used in?

Answer 2

atrial, nodal and ventricular tachycardia

Question 3

What does amiodarone block?

Answer 3

K+ channels - inhibiting repolarisation and prolonging action potential

Question 4

What is the class I effect of amiodarone?

Answer 4

blocks Na2+ channels

Question 5

How is amiodarone monitored?

Answer 5

• TFT, LFT, U&E, CXR prior to treatment
• TFT, LFT every 6 months

Question 6

What are the adverse effects of amiodarone?

Answer 6

• hypo & hyperthyroidism
• pulmonary fibrosis/pneumonitis
• liver fibrosis/hepatitis
• ‘slate-grey’ appearance
• bradycardia
• lengthens QT interval