Administration

Question 1

what is administration dependent on?

Answer 1

• physicochem properties
• dosage
  -site of action
  -digestion
  -metabolism
  -patient condition

Question 2

local vs systemic

Answer 2

topical vs intravenous > inhalation > sublingual > intradermal/ subcutaneous/ intramuscular > oral

Question 3

Lipinski rule of 5

Answer 3

<5 Hydrogen bond donors (NH or OH)
< 10 Hydrogen bond acceptors (all N and O atoms)
<500 molecular weight
logP < 5