Distribution

Question 1

Distribution

Answer 1

reversible transfer of drug to and from systemic circulation

Question 2

factors affecting distribution

Answer 2

• Pka
• lipophilicity
  -plasma protein binding (PPB)

Question 3

bioavailability

Answer 3

only unbound compounds are available for distribution

Question 4

serum albumin

Answer 4

acidic preference

Question 5

alpha - 1 - acid glycoprotein

Answer 5

basic preference