Amiodarone

Question 1

Amiodarone Trade Name?

Answer 1

Cordarone, Pacerone

Question 2

Amiodarone Classification?

Answer 2

Class III Antidysrhythmic

Question 3

Amiodarone Mechanism?

Answer 3

Blocks potassium channels causing prolongation of the action potential duration in all cardiac tissues. Also has blocking action on sodium channels, calcium channels and “alpha” and ‘beta” adrenergic receptors.

Question 4

Amiodarone Indications?

Answer 4

• Cardiac Arrest (VF, Pulseless VT)
• Stable Wide Complex Tachycardia

Question 5

Amiodarone Contraindications?

Answer 5

• Bradycardia
• High degree Heart block
• Hypersensitivity
• Hypotension (except in Cardiac Arrest)
• Cardiogenic shock

Question 6

Amiodarone Side Effects/Precautions?

Answer 6

• Dizziness
• Cough
• Shortness of breath
• CHF/Pulmonary edema
• Nausea
• Prolonged QT Interval
• Bradycardia
• Heart block
• Hypotension
• Burning at IV site

Question 7

Amiodarone Adult Dose?

Answer 7

• VF/VT arrest: 300 mg IVP followed by 150 mg IV/IO in 3-5 minutes
• Perfusing VT/malignant PVCs: 150 mg in 100 ml NS or D5W over 10 minutes IV drip
• Maintenance infusion: 1 mg/min for 8 hours, then 0.5 mg/min
• Do not exceed 2.2 grams per day

Question 8

Amiodarone Pediatric Dose?

Answer 8

• VF/VT arrest: 5 mg/kg (max 300 mg) IV/IO every 3-5 minutes, maximum 15 mg/kg or 450 mg
• Perfusing VT/malignant PVCs: 5 mg/kg IV/IO over 20-60 minutes

Question 9

Amiodarone Onset of Action?

Answer 9

Immediate

Question 10

Amiodarone Duration of Action?

Answer 10

30-45 Minutes

Question 11

Amiodarone Max Dose Adult/Pediatric?

Answer 11

Adult: NTE 2.2 grams in 24 hours
Peds: 450mg

Question 12

Amiodarone Routes of Administration?

Answer 12

IV/IO

Question 13

Amiodarone How Supplied?

Answer 13

150mg/3ml vials or prefilled syringes