Phenylepherine

Question 1

Phenylephrine Trade Name?

Answer 1

Neo-Synephrine

Question 2

Phenylephrine Classification?

Answer 2

Sympathomimetic, Decongestants, Intranasal

Question 3

Phenylephrine Mechanism?

Answer 3

Binds to A1 adrenergic receptors, second messenger release of calcum in VSMC, causing peripheral vasoconstriction, increasing SVR, increasing BP.

Question 4

Phenylephrine Indications?

Answer 4

• Non-hypovolemic shock, especially distributive shocks
• Hypotension in the peri-intubation period when
  using rapid sequence intubation

Question 5

Phenylephrine Contraindications?

Answer 5

Hypovolemia
Tachydysrhythmia

Question 6

Phenylephrine Side Effects/Precautions?

Answer 6

-Headache
-Syncope
-Tachycardia
-Hypertension
-Increased myocardial oxygen demand
-Dysrhythmia
-Nausea/Vomiting

Question 7

Phenylephrine Adult Dose?

Answer 7

• Loading dose: 100-180 mcg/min IV/IO infusion until BP>90 systolic
• Maintenance dose: 40-60 mcg/min
• For RSI. 50-200 mcg slow IV push every 2-5 minutes as needed for hypotension

Question 8

Phenylephrine Pediatric Dose?

Answer 8

0.1-0.5mcg/kg/min IV/IO infusion - titrate to normotensive systolic blood pressure

Question 9

Phenylephrine Onset of Action?

Answer 9

1 Minute

Question 10

Phenylephrine Duration of Action?

Answer 10

15-20 minutes

Question 11

Phenylephrine Max Dose Adult/Pediatric?

Answer 11

none noted in CT protocol or other researched locations

Question 12

Phenylephrine Routes of Administration?

Answer 12

IV/IO

Question 13

Phenylephrine How Supplied?

Answer 13

10mg/ml vials