Atropine

Question 1

Atropine comes in a vial with a concentration of __ mg/mL.

Answer 1

1 mg per mL

Question 2

Atropine MOA: Atropine is an ___. Increased ACh d/t reversal agents stimulates muscarinic receptors of the ___, __, and __.
These parasympathetic effects are unwanted during reversal therefore atropine is administered to block __, __, and __muscarinic ACh receptors.

Answer 2

anticholinergic

M2 in heart: bradycardia
M3 in glands: salivation & bronchial secretions
M3 in gut: cramping & diarrhea

Question 3

Atropine duration of action is approx __ to __ minutes.

Answer 3

30 to 60 minutes

Question 4

Atropine is paired with which acetylcholinesterase inhibitor for reversal of paralytics?

What is the dose of atropine used?

Answer 4

Edrophonium
7 to 10 mcg/kg

Question 5

M2 in heart: ___
M3 in glands: __ & __
M3 in gut: __ & __

Answer 5

M2 in heart: bradycardia
M3 in glands: salivation & bronchial secretions
M3 in gut: cramping & diarrhea

Question 6

The atropine dose for bradycardia is ___ mg IV. Repeat every __ to __ minutes as needed.

The maximum total dose: __ mg.

Answer 6

1 mg IV q 3-5 minutes
max dose 3 mg

Question 7

T/F: Atropine is preferred for bradycardia in cardiac patients.

Answer 7

False because it can cause tachycardia or myocardial oxygen demand spikes TOO fast.

Glycopyrrolate > atropine
1. Slower, more controlled increase in HR
2. Less risk of tachyarrhythmias
3. Better for patients with coronary artery disease or limited cardiac reserve