Induction Agent: Propofol

Question 1

What is the generic name of the drug commonly known as Diprivan?

Answer 1

Propofol

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Question 2

Propofol MOA: Propofol is a relatively selective modulator of ___ Type A receptors. Receptor activation causes transmembrane ___ conductance to increase leading to _____ of the postsynaptic cell membrane. This prevents ___ of impulses through the neuron and functional ___ of the postsynaptic neuron.

Propofol also potentiates activity at ___ receptors which partially contributes to ___ effect.

Answer 2

• Relatively selective modulator of gamma-aminobutyric acid (GABA) Type A receptors = principal inhibitory neurotransmitter in the brain.
• Receptor activation causes transmembrane CHLORIDE conductance to increase –> leading to hyperpolarization of the postsynaptic cell membrane –> therefore preventing transmission of impulses through the neuron and functional inhibition of the postsynaptic neuron.
• Also potentiates activity at glycine receptors –> partially contributes to hypnosis effect

Question 3

What is the standard concentration of Propofol used for anesthesia?

Answer 3

200 mg/20 mL
OR
10 mg/cc

(20cc vial standard). 1% lipid solution

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Question 4

PP: The typical induction dose of Propofol for an adult is ___ mg/kg.

TxWes Ref range: __ to ___mg/kg.

Answer 4

PP: 2 mg/kg IV

TexWes Ref: 1.5-2.5 mg/kg

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Question 5

For sedation, the dose range of Propofol is __ to __ mcg/kg/min.

Answer 5

25–100 mcg/kg/min

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Question 6

The typical dose range of Propofol for Total Intravenous Anesthesia (TIVA) is __ to __ mcg/kg/min.

Answer 6

100–300 mcg/kg/min

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Question 7

The context-sensitive half-time (the time for a drugs blood concentration to drop by 50% after a continuous infusion stops) of Propofol is > ____ minutes and does accumulate with long therapy.

Answer 7

> 40 minutes

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Question 8

Propofol’s elimination half-life ranges between __ to __ hours.

Answer 8

0.5 to 1.5 hours

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Question 9

In low doses Propofol can be used as a rescue medication to treat __________.

Answer 9

PONV Postoperative nausea and vomiting

10-15 mg followed by gtt at 10 mcg/kg/min

Question 10

Tex Wes Ref: The onset time of propofol is __ to __ seconds.

Answer 10

30 to 60 seconds

Question 11

Tex Wes Ref: The duration of action time of propofol is __ to __ minutes.

Answer 11

1 to 8 minutes