Narcotics: Morphine

Question 1

Morphine MOA: Morphine is classified as an __________, meaning it binds to and activates opioid receptors.

Answer 1

Agonist

Throw back to Dr. T

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Question 2

PP & TexWes Ref: What is the typical IV dose range for Morphine when used for post-operative pain management?

Answer 2

5-20 mg titrated

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Question 3

Morphine has dose-dependent release of which chemical that may lead to side effects such as hypotension or itching?

Answer 3

Histamine

High doses decrease PVR.

Question 4

True or False

Describe the 2 metaboiltes of morphine:

Answer 4

Morphine-6-glucuronide (M6G):
More potent than morphine and is responsible for the analgesic effect of morphine

Morphine-3-glucuronide (M3G):
An inactive metabolite that may produce excitatory effects and is responsible for some side effects of high-dose morphine

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Question 5

TexWes Ref: Morphine Intra op dose is ___ mg.

Answer 5

1-10 mg

Question 6

TexWes Ref: The onset for Morphine is ___ min.

Answer 6

10-20 minutes

Question 7

TexWes Ref: The duration of Morphine is __ to __ hours.

Answer 7

4-5 hours