Heparin

Question 1

Heparin MOA: Heparin binds to ___→ directly inhibits soluble __ which is factor __ and factor __ which is also called activated __-__.

Answer 1

Heparin binds to antithrombin → directly inhibits soluble thrombin (factor II) and Xa (activated Stuart-Prower)

“Heparin Helps Antithrombin Halt Clotting”

H → Heparin

H → Helps

A → Antithrombin III

H → Halt

C → Clotting (by inactivating thrombin IIa and factor Xa)

Question 2

The reversal for heparin is ___.
__ mg of __ will inhibit __ mg of heparin.

Answer 2

Reversal = PROTAMINE
1 mg protamine will inhibit 1 mg heparin

Question 3

Dose & re-dosing: Ask Jacob LOL.

Answer 3

:)

Question 4

Heparin has a concentration of __ units/mL

Answer 4

1000 units per mL