autoreceptors Flashcards by nysa .

Q

Where is Muscarinic M1 receptor found?

A

CNS neurons

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Q

What happens when Muscarinic M1 is activated?

A

Formation of IP₃ and DAG

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Q

Where is Muscarinic M2 receptor found?

A

Myocardium

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Q

What happens when Muscarinic M2 is activated?

A

Opening of potassium channels

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Q

Where is Muscarinic M3 receptor found?

A

Exocrine glands

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Q

What happens when Muscarinic M3 is activated?

A

Like M₁ receptor-ligand binding

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Q

Where is Muscarinic M4 receptor found?

A

CNS neurons; possibly vagal nerve endings

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Q

What happens when Muscarinic M4 is activated?

A

Like M₂ receptor-ligand binding

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Q

Where is Muscarinic M5 receptor found?

A

Vascular endothelium (especially cerebral vessels); CNS neurons

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Q

What happens when Muscarinic M5 is activated?

A

Like M₁ receptor-ligand binding

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Q

Where is Nicotinic NN receptor found?

A

Postganglionic neurons

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Q

What happens when Nicotinic NN is activated?

A

Opening of Na⁺

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Q

Where is Nicotinic NM receptor found?

A

Skeletal muscle neuromuscular end plates

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Q

What happens when Nicotinic NM is activated?

A

Opening of Na⁺

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Q

Where is Alpha1 receptor found?

A

Postsynaptic effector cells

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Q

What happens when Alpha1 is activated?

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A

Formation of IP₃ and DAG

Q

Where is Alpha2 receptor found?

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A

Presynaptic adrenergic nerve terminals

Q

What happens when Alpha2 is activated?

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A

Inhibition of adenylyl cyclase

Q

Where is Beta1 receptor found?

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A

Heart

Q

What happens when Beta1 is activated?

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A

Stimulation of adenylyl cyclase

Q

Where is Beta2 receptor found?

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A

Smooth muscle and cardiac muscle

Q

What happens when Beta2 is activated?

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A

Stimulation of adenylyl cyclase

Q

Where is Beta3 receptor found?

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A

Lipocytes; heart

Q

What happens when Beta3 is activated?

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A

Stimulation of adenylyl cyclase

Where is Dopamine D1 (DA1) and D5 receptor found?

Brain; renal vascular smooth muscle

What happens when D1/D5 is activated?

Stimulation of adenylyl cyclase

Where is Dopamine D2 (DA2) receptor found?

Brain; smooth muscle; presynaptic nerve terminals

What happens when D2 is activated?

Inhibition of adenylyl cyclase; increased potassium conductance

Where is Dopamine D3 receptor found?

Brain

What happens when D3 is activated?

Inhibition of adenylyl cyclase

Where is Dopamine D4 receptor found?

Brain

What happens when D4 is activated?

Inhibition of adenylyl cyclase