dobutamine

Question 1

Mechanism of Action: Primary Receptor

Answer 1

Beta-1 (β1) Adrenergic Agonist

Question 2

Why is Dobutamine a ‘racemic mixture’?

Answer 2

(+) Isomer = β1 agonist & α1 antagonist; (-) Isomer = α1 agonist

Question 3

Drug of Choice: Pharmacological Stressor

Answer 3

Dobutamine

Question 4

Pharmacokinetics: Half-life and Route

Answer 4

2 minutes; Continuous IV Infusion

Question 5

Reasoning: Why preferred over Dopamine in Heart Failure?

Answer 5

Dobutamine reduces afterload (SVR) and filling pressures.

Question 6

Reasoning: Why is it called an ‘Inodilator’?

Answer 6

Positive Inotropy + Vasodilation

Question 7

NEET PG Pearl: Effect on Myocardial Oxygen Demand

Answer 7

Increases significantly

Question 8

Major Contraindication: Structural Heart Disease

Answer 8

HOCM (IHSS)

Question 9

Reasoning: Why monitor K+ levels during infusion?

Answer 9

Risk of Hypokalemia

Question 10

Metabolism: Key Enzyme

Answer 10

COMT (Catechol-O-methyltransferase)

Question 11

Clinical Sign: Tolerance/Tachyphylaxis

Answer 11

Occurs after 72 hours of continuous use