Cartilage Flashcards

Lecture 3 (38 cards)

1
Q

What is cartilage?

A

Cartilage is a specialized type of connective tissue. Composed of hyaline, elastic and fibrocartilage types. It consists of collagenous fibers embedded in a firm matrix of
chondroitin sulfates. Caritilage consists of cells + the substances they produce which form the matrix.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the specialised forms of connective tissue in the skeletal system?

A

cartilage, bones, ligaments and tendons.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the function of cartilage?

A

provides semi-rigid support in certain sites.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the function of bones?

A

provide a strong supporting framework for soft tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the function of ligaments?

A

They are strong bands of connective tissue that stabiles joints.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the function of tendons?

A

They are strong bands of connective that connects muscle to bone.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does cartilage consist of?

A

cells and the substances they produce which form the matrix.
* The mature cell in all cartilage is the chondrocyte.
* These cells sit in spaces called lacunae.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the chondrocyte + where is it found?

A

The mature cell in all cartilage - they sit in spaces called lacunae.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How is the matrix formed?

A

Chondrocytes produce material/secrete substances which form the matrix.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does the matrix consist of?

A

The matrix is composed largely of two things:
- A gel-like fluid called ground substance.
- Protein fibers made up or collagen and/or elastin.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How many types of cartilage in the human body?

A

3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the types of cartilage in the human body?

A
  • Hyaline cartilage
  • Elastic cartilage (elastin fibres in the matrix)
  • Fibrocartilage (collagen fibres in the matrix)
    Each type has a diff matrix composition.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is hyaline cartilage?

A

Most abundant type of cartilage.
It has a perichondrium. Hyaline cartilage provides support with some
flexibility.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does hyaline cartilage form?

A

Forms precursor of bone in the developing skeleton

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where is hyaline cartilage found?

A

Found in joint surfaces, nasal septum, larynx,
tracheal rings, bronchi, sternal ends of ribs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are chondrocytes?

A

Chondrocytes are living cells that require nutrients

17
Q

What are Isogenous groups?

A

Chondrocytes clusters in hyaline cartilage.

18
Q

What does avascular mean?

A

Cartilage is avascular – it does not have a blood supply.

19
Q

What is the perichondrium?

A

The perichondrium is a connective tissue covering
that surrounds cartilage.
* It contains blood vessels and nutrients and waste
diffuse in to and out from the chondrocytes.
* Reason why cartilage heals very slowly.
** No perichondrium in hyaline cartilage in joints **

20
Q

What part of hyaline cartilage does not have perichondrium?

A

In joints of hyaline cartilage there is no perichondrium.

21
Q

How do chondrocytes get nutrients?

A

The perichondrium, which surrounds cartilage, contains blood vessels, & nutrients + wastes diffuse in to and out from the chondrocytes.

22
Q

Why does cartilage heal slowly?

A

The perichondrium is a connective tissue covering
that surrounds cartilage.
* It contains blood vessels and nutrients and waste
diffuse in to and out from the chondrocytes.
* Reason why cartilage heals very slowly.

23
Q

What is articular cartilage in synovial joints?

A

Hyaline cartilage covering the end of long bones is called articular cartilage.
* Specialized type of hyaline cartilage.
* Means very little friction to allow easy movement. Helps to absorb stress on the joints.
Fibrocartilage provides
some compressibility and can absorb pressure.

24
Q

Do synovial joints have a perichondrium?

A

No perichondrium à bathed and nourished
by the synovial fluid in the joint.

25
How is articular cartilage divided?
Usually divided into a numbers of layers based on chondrocyte arrangement; * Tangential layer. * Transitional layer * Radial layer
26
Articular cartilage function:
Very little friction to allow easy movement; helps to absorb stress on the joints.
27
What is elastic cartilage?
*Is like hyaline cartilage but with bundles of elastin scattered in the matrix. * More elastic than hyaline cartilage. *Has a perichondrium. Elastic cartilage provides firm but elastic support.
28
Where is elastic cartilage found?
In the external ear, and several tubes, e.g. external auditory canal, epiglottis, larynx, walls of Eustachian tubes.
29
How are chondrocytes arranged in elastic cartilage?
Chondrocytes are more closely packed and usually found singly, rather than in clusters.
30
What is fibrocartilage?
Somewhat like hyaline cartilage but with strong bundles of collagen in the matrix. Resists compression and shear forces. Collagen fibres are strong and tough, => fibrocartilage is found in areas that experience a lot of compressive forces.
31
How are chondrocytes arranged in fibrocartilage?
Chondrocytes arranged in rows between thick collagen fibres.
32
Does fibrocartilage have a perichondrium?
Does not have a perichondrium => nourished from blood vessels in local tissues.
33
Where is fibrocartilage found?
Collagen fibres are strong and tough, => fibrocartilage is found in areas that experience a lot of compressive forces. Fibrocartilage is found: * intervertebral discs (shown here) * Joint capsules * Ligaments, tendons * Mensci in the knee joint * Pubic symphysis
34
What is the disease of cartilage?
Osteoarthritis
35
What is osteoarthritis?
degenerative joint disease, characterized by articular cartilage loss (‘wear & tear’) -narrowing of the the joint space and bone to bone contact Disease of synovial joints: knee, fingers, hips, feet
36
Osteoarthritis symptoms:
* Pain or aching in a joint during activity * Joint stiffness usually occurs first thing in the morning or after resting * Limited range of motion that may go away after movement * Clicking or popping sound when a joint bends * Swelling around a joint * Muscle weakness around the joint
37
How is osteoarthritis diagnosed?
physical exam and imaging tests (X-ray, MRI, CT)
38
What is the therapy for osteoarthritis?
* Physical Therapy * Occupational Therapy (toothbrush with a large grip) * Steroid injections * Lubrication injections * Joint replacement * Cortisone injection