chapter 6 section 2

Question 1

What dictates how a protein folds into its three-dimensional structure?

Answer 1

folding is encoded in the amino acid sequence.

Question 2

Are the forces that determine protein structure internal, external, or both?

Answer 2

Both – within the protein and between the protein and solvent.

Question 3

What may initiate protein folding along the peptide chain?

Answer 3

Nucleation points at specific loci along the chain.

Question 4

What must the folding process avoid to reach the native structure?

Answer 4

Local energy-minimum states that are not the native state.