chemo

Question 1

inhibit cell growth at M phase

Answer 1

• paclitaxel: stabilizes microtubules halting cycle

- vincristine: destabilizes microtubes halting cycle

Question 2

methotrexate (MOA… SE… antidote…)

Answer 2

• inhibits dihydrofolate reductase, acts as a folic acid analogue
• SE: erythema, rash, urticaria, and MYELOSUPPRESSION
• tx for myelosupression: leucovorin, bypasses the reductase step, allows bone marrow to recover

Question 3

filgrastim

Answer 3

• given to patients on myelosuppressive chemotherapy to help bone marrow recover
• also called granulocyte colony stimulating factor (G-CSF)