tricyclic SE (mnemonic)
-red as a beet, dry as a bone, hot as a hare, blind as a bat, mad as a hatter, full as a flask
clozapine (tx, MOA, SE)
- schizophrenia
- block dopamine AND serotonin (atypical)
- agranulocytosis
atypicals
- olanzapine, clozapine, quetiapine, risperadone, aripiprazole, ziprasidone
- less extrapyramidal signs
- agranulocytosis with clozapine
- weight gain with olanza and clozapine
lithium overdose
- nephrogenic DI
- confusion, memory loss, ataxia, coarse hand tremors
lithium and pregnancy
- ebstein’s anomaly
- downward displaced tricuspid, enlarged right atrium, small hypo functioning right atrium
lithium SE
-nephrotoxic (nephrogenic DI) and thyrotoxic
benefit of bupropion
-less sexual side effects
tricyclic MOA
-inhibition of presynaptic uptake of serotonin and norepi
antisocial personality disorder is often comorbid with…
-substance abuse disorders
tx for callouses on knuckles and swelling over rami of mandible?
-SSRI for bulimia
association with autism?
-tuberous sclerosis
benzo overdose tx (and MOA)
- flumazenil
- competitive antagonist
conversion disorder
- pseudoseizure, vocal cord dysfunction, blindness etc.
- mimics dysfunction in voluntary system
serotonin syndrome drugs
- MAOI***
- TCA
- SSRI
- lithium
- meperidine
- sumatriptan
- St. Johns Wort
MAOI is better than TCA if concerned about…
- heart
- anticholinergic problems: BPH
short acting benzos
-oxazepam, triazolam, midazolam
buspirone
- anxiolytic, different MOA than benzo or barb
- no dependence risk
- 2-3 wks for onset of action
hydroxyzine
-antihistamine H1 blocker, used to treat pruritis…. and anxiety without too many SE
somatic symptom disorder
-many somatic complaints
splitting…
- dichotomy disorder
- things are either/or, all good, all bad
- often seen in pts with borderline personality disorder along with cutting, burdening etc
reaction formation
-burnt out doctor mentoring medical students and encouraging them to continue
most common SSRI side effect…
-GI complaints
schizoid personality disorder
- socially withdrawn
- hermit disease
