bleomycin (MOA… and SE)
- has unique ability to bind DNA and iron simultaneously, oxidized iron then damages DNA (superoxide and hydroxide radicals)
- pulmonary fibrosis and hyperpigmentation
methotrexate (MOA, SE, tx for SE)
- inhibits dihydrofolate reductase –> decreases thymidine
- myelosuppression, glossitis, mucositis
- leucovorin rescue (folinic acid)
- can also be used as immunosuppressant and abortifacient
name a common alkylating agent and its dangerous SE that is treated prophylactically with…
- cyclophosphamide
- hemorrhagic cystitis
- mesna
tacrolimus (use, MOA) bonus point for fun fact related to hearts
-transplant immunosuppression
-calcineurin inhibitor, binds to FK-binding protein, inhibits interleukin-2 secretion –> prevents activation and differentiation of T cells
(also used on drug eluting stents to prevent fibrosis)
filgrastim is a….
-granulocyte colony stimulating factor
BEP regimen, (3 drugs (p is trixy), and what it is indicated for)
- bleomycin (free radical generation … pulmonary fibrosis and hyperpigmentation)
- etoposide (G2 specific topoisomerase inhibitor … myelosupression and alopecia)
- cisplatin (crosslinking of DNA … nephrotox)
- used for testicular cancer (seminoma)
methimazole (tx for… MOA… SE…)
- hyperthyroid
- prevents iodination of thyroglobulin
- agranulocytosis
anti-neoplastic microtubule drugs (2… and MOA… and SE… what phase is the cell in)
- vinca alkaloids, inhibit formation of microtubules, neurotox
- paclitaxel, prevents breakdown of microtubules, myelosuppression and alopecia
- M phase
busulfan (MOA… SE (or tx?)…
- an alkylating agent that crosslinks DNA
- pulmonary fibrosis, hyperpigmentation and…..
- *bone marrow suppression in 100%** can be used for this purpose in transplant patients
recombinant IL-2 is used to treat… along with… because
- renal cell carcinoma
- surgical excision
- getting rid of primary tumor can decrease MET burden
trastuzumab is used to treat….(subtype) and is a …. (class)
- breast cancers expressing HER2 (or erbB2)
- monoclonal antibody
carcinoid secretes… which is subject to first pass metabolism, so it usually doesn’t present until…
- serotonin
- METS
bevacizumab (what is it, what do you treat with it?)
- monoclonal antibody against VEGF (decreased vascular growth)
- tx: several solid tumor cancers–> colon, breast, small cell lung
drugs that cause alopecia and their MOA
- paclitaxel … prevents microtubule breakdown (M phase)
- etoposide … prevents DNA unwinding via topoisomerase II inhibitor (G2 phase)
alpha-interferon, uses?
-HBV, HCV, leukemias, kaposi and malignant melanoma
gamma-interferon, uses?
- CGD
- normally produced by t-lymphocytes
tx for hodgkin … (4 letter acronym)
- ABVD
- (brand name that starts with A…) doxyrubicin
- bleomycin
- vinblastine
- dacrabazine
hemorrhagic cystitis is caused by… and can be prevented by treatment with… (2)
- cyclophosphamide
- mesna or N-acetylcysteine
vincristine is a …. which stops cell cycle at … phase, but can have … SE
- microtubule inhibitor
- M phase
- neurotox: areflexia, peripheral neuritis, paralytic ileus
vinblastine is a … which stops cell cycle at … phase, but can have … SE
- microtubule inhibitor
- M phase
- myelosuppresion (blastine blasts bone)
anti-VEGF drugs (3)
- bevacizumab
- sorafenib
- sunitinib
