pulm

Question 1

pentamidine

Answer 1

-first line in PCP (pnuemocystis jirovici) if pt is allergic to sulfa

Question 2

N-acetylcysteine… 2 uses

Answer 2

• tylenol overdose

- mucolytic for CF

Question 3

theophylline (MOA, tx for, antidote)

Answer 3

• bronchodilation via increasing intracellular cAMP
• asthma
• B blocker (cardio selective please)

Question 4

enteracept (MOA, and relation to another disease)

Answer 4

• TNF-alpha inhibitor
• used in to treat RA
• TNF is necessary to recruit macrophages, especially in disease like TB when the macrophages help maintain granulomas– enteracept can cause secondary reactivation of TB

Question 5

INH (isoniazid) MOA

Answer 5

-inhibition of mycolic acid synthesis

Question 6

ipraytropium

Answer 6

-anticholinergic bronchodilator used in COPD

Question 7

first line therapy for TB when pts can’t tolerate or bug is resistant to INH… (and SE)

Answer 7

• ethambutol

- red-green color blindness and decreased visual acuity

Question 8

treatment for TB is RIPE

Answer 8

• rifampin
• INH
• pyrazinamide
• ethambutol

Question 9

weird side effect of rifampin… (also MOA?)

Answer 9

• turns all bodily secretions orange

- MOA: inhibits DNA dependent RNA polymerase

Question 10

tx for nocardia asteroides

Answer 10

-sulfas

Question 11

Zileuton (MOA) and Zafirlukast (MOA)

Answer 11

• zileuton, prevents conversion of arachidonic acid into leukotrienes (potent bronchoconstrictors)
• zafirlukast, leukotriene receptor blocker

Question 12

three cephalosporins that can treat pseudomonas?

Answer 12

-cefoperazone, ceftazidime, cefepime

Question 13

potential SE of zileuton which requires…. tests to be done before starting therapy

Answer 13

• elevation of liver enzymes…

- LFTs

Question 14

prophylaxis for TB (1.5 drugs)

Answer 14

-INH and pyridoxine (B6)