1
Q
Brand Name of Clopidogrel
A
Plavix
2
Q
Drug Class
A
Anti-platelet
3
Q
Mechanism of Action
A
Non-competitive platelet antagonist. Prevents release of ADP granules form activated platelets, reducing ability to activate further platelets.
4
Q
Indications
A
Alternative (or additional adjunct) to aspirin in pt.’s w/ CP suggestive of MI, post MI and post stent placement
5
Q
Contraindications
A
Active GI bleeding, intracranial hemorrhage
6
Q
Adverse Effects
A
GI bleeding, thrombotic thrombocytopenic purpura, cerebral hemorrhage
7
Q
Precautions
A
Nexium and Prilosec may exhibit effects of Plavix
8
Q
Dose and Administration
A
300-600mg loading dose PO (then 75mg daily PO)
Pharmacology
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