1
Q
Generic Name
A
Pralidoxime
2
Q
Brand Name
A
2-Pam, Protopam,Duodote
3
Q
Drug Class
A
Antidote
4
Q
Mechanism of Action
A
Reactivates cholinesterase and blocks runaway stimulation of parasympathetic nervous system
5
Q
Indications
A
Organophosphate poisoning and nerve agent poisoning
6
Q
Contraindications
A
Impaired renal function, mysthenia gravis, inorganic phosphate poisoning
7
Q
Adverse Effects
A
Dizziness, drowsiness, H/A, muscle rigidity, neuromuscular blockade, laryngospasm
8
Q
Precautions
A
Do not use with other resp. depressants, succinylcholine, or theophylline
9
Q
Dose and Administration
A
600mg IM auto-injector q 15 minutes (max 3)
IV infusion 1-2g over 30-60minutes
Pharmacology
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