COMPLEMENT SYSTEM

Question 1

________________ is the lysis of cells such as bacteria, virus infected cells, and tumor cells

Answer 1

cytolysis

Question 2

Cytolysis

process occurs through the development of the MAC
composed of

Answer 2

C5B, 6,7,8,9

Question 3

_________ is the directed movement of leukocytes up a gradient concentration toward the site of infection

Answer 3

chemotaxis

Question 4

_________ is the term used to describe how antibodies of C3b can enhance phagocytic engulfment of microbes

Answer 4

opsonization

Question 5

___________ promote vasodilation and increase vascular permeability

two components are ____ and ____

Answer 5

anaphylatoxins
C3a C5a

Question 6

PRODUCTS OF COMPLEMENT ACTIVATION

stimulates release of neutrophils from the bone marrow

Answer 6

C3

Question 7

PRODUCTS OF COMPLEMENT ACTIVATION

Weak anaphylatoxin, spasmogen

Answer 7

C4a

Question 8

PRODUCTS OF COMPLEMENT ACTIVATION

virus neutralization, opsonin, co-factor for convertases

Answer 8

C4b

Question 9

PRODUCTS OF COMPLEMENT ACTIVATION
terminal component complex or MAC

Answer 9

C5a

Question 10

REGULATION OF COMPLEMENT SYSTEM

important regulator of classical pathway
irreversibly binds to and inactivates C1r and C1s as well as MASP in lectin pathway

Answer 10

C1 inhibitor

Question 11

REGULATION OF COMPLEMENT SYSTEM

regulates alternative pathway
reduce abmount of C5 convertase available

Answer 11

Factor H

Question 12

REGULATION OF COMPLEMENT SYSTEM
protects C3b and stabilizes C3 convertase in alternative pathway

Answer 12

properdin

Question 13

REGULATION OF COMPLEMENT SYSTEM

cleaves cell bound or fluid phase C3b and C4b which inactivates C3b and C4b

Answer 13

factor I

Question 14

REGULATION OF COMPLEMENT SYSTEM

glycoprotein on surface of human cells

Answer 14

decal accelerating factor

Question 15

REGULATION OF COMPLEMENT SYSTEM

inhibits action of C4b in classical pathway

Answer 15

C4b Binding Protein

Question 16

CLINICAL ASPECTS

predispose to severe neisseria bacteremia

Answer 16

C5-C8 deficiency
mannan binding lectin

Question 17

CLINICAL ASPECTS

severe recurrent pyogenic sinus and resp. tract infections

Answer 17

deficiency of C3

Question 18

CLINICAL ASPECTS

angiodema

Answer 18

def. of C1 esterase inhibitor

Question 19

CLINICAL ASPECTS

increased complement mediated hemolysis
paroxysmal nocturnal hemoglobinuria

Answer 19

DAF deficiency

Question 20

BIOLOGIC EFFECTS:
_________: Opsonization; enhance Phagocytosis
_________: C5a, C567 complex - attract neutrophils; C5a enhance adhesiveness of neutrophils to endothelium
_________: Anaphylatoxins - cause degranulation of mast cells; bind directly to smooth muscles to bronchioles causing bronchospasm
_________: cytolysis; disrupts membranes
_________: opsonin with receptor on surface of B cells -> enhance antibody production

Answer 20

C3b and C1q
C5a, C567
C3a, C4a, C5a
MAC
C3b

Question 21

THREE PATHWAY OF COMPLEMENT ACTIVATION:
________: antibody dependent pathway and triggered by formation of soluble antigen-antibody complex or by binding of the antibody to the antigen present on the target cell surface

Answer 21

CLlassical pathway

Question 22

THREE PATHWAY OF COMPLEMENT ACTIVATION:
_________ is antibody independent pathway stimulated by antigen directly example is the bacterial cell surface components

_________ is also antibody independent but resembles classical pathway

Answer 22

alternative pathway
lectin pathway

Question 23

CLASSICAL PATHWAY
immunoglobulins involved: ________ and ______ (except IgG4)

C1 can interact directly with some pathogens and can also interact with antibodies
-> which allows complement to function in both innate and adaptive immunity

Answer 23

IgM and IgG

Question 24

COMPONENTS OF THE MAC

Native component
C5 -> _________ - mediates inflammation; anaphylatoxin, chemotaxin

__________- initiates assembly of the Membrane Attack complex (MAC)

Answer 24

C5a; C5b

Question 25

Alternative Pathway Bypasses ___,_____, and _______ acts synergistically with the classical pathway

Answer 25

Bypasses C1. C4, and C2

Question 26

COMPLEMENT COMPONENT ________ and _________; opsonization enhance phagocytosis _________; anaphylatoxins - cause degranulation of mast cells; bind directly to smooth muscles of bronchioles causing bronchospasm ________; cytolysis; disrupts membrane ________; opsonin; with receptors on surface of B cells - enhance antibody production

Answer 26

C3b and C1q C3a, C4a, C5a MAC C3b