MicroBio-Virus > Coronavirus > Flashcards

Coronavirus Flashcards

(19 cards)

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1
Q

Nucleic acid of a coronavirus

A

positive SS RNA, non-segmented

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2
Q

Does coronavirus require polymerase

A

No, positive strand RNA acts like an mRNA

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3
Q

Capsid of a coronavirus

A

Helical capsid

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4
Q

Envelope of coronavirus

A

Derived from intracellular membranes and NOT from the plasma membrane.

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5
Q

Replication of coronavirus occurs

A

Within the cytoplasm

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6
Q

Protein that coronavirus binds to

A

-S protein bind to aminopeptidase N and sialic acid

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7
Q

Protein that is translated by for coronavirus

A
  1. translation of a RNA-dependent RNA polymerase
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8
Q

RNA dependent RNA polymerase encodes

A
  1. full length, (-) sense RNA template

2. six mRNAs for coronavirus proteins

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9
Q

Organelle the virion enter into

A

Rough endoplasmic reticulum

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10
Q

Virion released by cell by

A

exocytosis

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11
Q

Clinical presentation of Coronavirus

A
  1. Common cold; upper respiratory tract infection, self-limited
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12
Q

Incubation period for coronavirus

A

3 days

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13
Q

Symptoms of common cold

A
  1. sore throat, runny nose, congestion, sneezing, coughing

2. muscles aches, fatigue, headache

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14
Q

Cells coronavirus infects

A

epithelial cells of upper respiratory tract

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15
Q

Immune response to coronavirus

A
  1. infected cells; vacuolated, damaged cilia, syncytial
  2. production of inflammatory mediators, cause local swelling and inflammation
  3. stimulate sneezing, obstruct airway, raise temperature
  4. increased of interferon and antibodies
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16
Q

Epidemiology of coronavirus

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A

-10 to 15% of UR infections and pneumonia

17
Q

What allows survival of coronavirus

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A

Glycoprotein corona: helps virus survive GI and transmit fecal route

18
Q

Transmission of coronavirus

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A
  1. Aerosal
  2. hand to hand
  3. object to hand
19
Q

Control

MicroBio-Virus
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