Rabies

Question 1

Family that Rabies is in

Answer 1

Rhabdovirus

Question 2

Main complication of Rabies

Answer 2

-infects CNS causing encephalopathy

Question 3

Capsid structure

Answer 3

Helical

Question 4

Is it enveloped

Answer 4

Yes

Question 5

Genome of Rabies

Answer 5

• negative
• single stranded
• RNA

Question 6

Replication occurs where in the cell

Answer 6

Cytoplasm

Question 7

Replication process for Rabies

Answer 7

1. binds G-proteins on surface
2. virus penetrates host cell via pinocytosis
3. virus enters endosome, releasing into cytoplasm
4. Viral polymerase transcribe genome into 5 mRNA and (+) RNA template
5. Translation
6. Replication
7. Assembly
8. Bud from plasma membrane

Question 8

The function of the 5 proteins N, P, M, G, L proteins

Answer 8

• NPL complex encapsulate (-) RNA to form RNP core
• M protein forms a capsule around RNP
• G protein processed in ER and Golgi

Question 9

Incubation period of rabies

Answer 9

20 to 90 days

Question 10

Description of the prodromal phase

Answer 10

• similar to flu: weakness, discomfort, fever, headache

- discomfort or itching sensation at the site of bite

Question 11

Description of neurological phase

Answer 11

• cerebral dysfunction, anxiety, confusion, agitation
• acute confusion, abnormal behavior, insomnia, hallucinations
• coma, hypotension, cardiac arthymia

Question 12

Problem when symptoms appear

Answer 12

Death is imminent

Question 13

Pathogenesis of rabies

Answer 13

1. Virus enters animal bite
2. virus replication in muscle at site of bite
3. Virus infects PNS, moves by retrograde transport
4. Virus replicates DRG, travels up spinal cord to brain
5. Brain infected
6. travels from brain to others tissues via nerves

Question 14

Where does the virus concentrate in

Answer 14

Salivary glands

Question 15

Most popular symptom is

Answer 15

Hydrophobia; virus invades and damages muscles involved with drinking and swallowing

Question 16

Common reservoir for rabies

Answer 16

-bats, foxes, raccons, skunk

Question 17

transmission of rabies

Answer 17

bite, scratch

Question 18

Diagnosis of rabies

Answer 18

• histopathology
• electron microscopy
• direct fluorescent antibody test
• immunohistochemistry

Question 19

Diagnosis of rabies

Answer 19

1. mononuclear infiltration
2. perivascular cuffing of lymphocytes or polymorphonuclear cells
3. lymphocytic foci
4. babes nodules consisting of glial cells
5. negri bodies

Question 20

Control of rabies

Answer 20

• specific immunoglobin immunization

- vaccine started and 3 doses