RSV

Question 1

What does RSV stand for?

Answer 1

Respiratory Syncytial Virus

Question 2

RSV is responsible for the most common what in infants and young children?

Answer 2

Fatal acute respiratory tract infections

Question 3

Host of RSV

Answer 3

Only humans

Question 4

Genome of RSV

Answer 4

• negative
• single stranded
• RNA

Question 5

Capsid of RSV

Answer 5

Helical

Question 6

Distinguishable clinical presentation of RSV

Answer 6

Infants/Young : Lower respiratory tract infections and bronchiolitis

Older: Upper respiratory tract infections and flu like symptoms

Question 7

Other symptoms associated with RSV

Answer 7

-flu like symptoms

Question 8

Does RSV cause viremia

Answer 8

No

Question 9

Transmission of RSV

Answer 9

Aerosols and direct contact

Question 10

What is Bronchiolitis

Answer 10

• virus induced necrosis of the bronchiolar epithelium
• hypersecretion of mucus
• inflammatory cell infiltration
• edema

Question 11

Pathology of RSV

Answer 11

-multinucleated giant cells

Question 12

Diagnosis of RSV

Answer 12

• fluorescent antibody
• antigen detection
• PCR detection of RNA

Question 13

Treatment of RSV

Answer 13

1. Ribavirin; causes replication/transcription errors and is a G analogue. Also used for flavi, paramxo, bunya, arena, retro, herpes, adeno, pox

Question 14

Treatment of RSV that is not an analogue

Answer 14

Palivizumab; a monoclonal antibody which provides passive immunization.