Polyomaviridae

Question 1

Viruses of polyomaviridae

Answer 1

1. BK and JC viruses

2. SV40(simian polyomavirus) and murine polyomavirus

Question 2

Structure of polyomaviruses

Answer 2

Smaller, less complex than papillomavirus

Question 3

Replication locations of BK and JC

Answer 3

JC - respiratory tract, urinary tract, CNS

BK - respiratory tract, urinary tract

Question 4

Patients susceptible to infection

Answer 4

immunocompromised patients

Question 5

Pregnancy and BKJC viruses

Answer 5

viruses reactivated during pregnancy, no transmission to baby

Question 6

Clinical presentation of a BK viral infection

Answer 6

1. Ureteral stenosis in renal transplant patients

2. hemorrhagic cystitis in bone marrow transplant patients

Question 7

Clinical presentation of a JC viral infection

Answer 7

Progressive multifocal leukoencephalopathy(PML)

• virus infects oligodendrocyte cells, resulting in loss of white matter
• changes to speech, vision, coordination, mental
• paralysis and death

Question 8

Prognosis of PML

Answer 8

1 to 4 months, death within 2 years

Question 9

Pathogenesis of BK and JC

Answer 9

• enter into respiratory tract, infect lymphocytes, and then kidney
• BK establishes latent infection in kidney
• JC infection in kidneys B cells, monocyte lineage cells
• viral shedding in urine, severe urinary infection BK
• viremia and CNS infection, JC

Question 10

Control

Answer 10

none