Diazepam

Question 1

Introduction

Answer 1

Anticonvulsant - sedative

Question 2

Pharmacodynamics

Answer 2

• CNS depressant
• Acts on agonising GABBA by opening the Chlorine channels in the cell, and repolerising it, reduces the excitability across the cells synapse.
• Needs a greater Action Potential to fire of due to hyperpolerised cell

Question 3

Pharmacokinetics

Answer 3

• IV/PR
• Widely Disributed
• Hepactically
• Eliminated Renally

Question 4

Presentation

Answer 4

• Ampoule 10mg/2ml

- Rectel Tube 2.5mg, 5mg, 10mg

Question 5

Why would you give the drug

Answer 5

• Fits longer then 5mins and still Fitting
• Repeated Fits
• Status epilepticus 30mins
• Eclampic Fits
• Cocaine systematic chest pain.

Question 6

Dose

Answer 6

• IV = 10mg/2ml repeated 10mg/2ml
• Rectal = 20mg
• Max 20mg

Question 7

Side Effects

Answer 7

• Resp Depression
• Hypotension
• Drowsiness
• Confusion
• Ammnesia