Warfarin

Question 1

Introduction to the drug

Answer 1

• Warfarin is an synthetic anti coagulant drug given short or long term to patients at risk or for treatment of blood clots. For example Deep vein thrombosis or pulmonary embolism.

Question 2

Presentation of the drug

Answer 2

0.5mg, 1mg, 3mg and 5mg tablets.

Question 3

Why would you prescribe the drug

Answer 3

• Treatment or prophylaxis of blood clots ie PE/DVT.

- pts with atrial fibrillation again to prevent clot formation

Question 4

Typical dose

Answer 4

10mg for two days then dependant on INR

Question 5

Pharmacodynamics of the drug

Answer 5

• Warfarin inhibits the synthesis of vitamin K which effects the clotting factors II,VII, IX and thus reducing clot formation

Question 6

Pharmacokenetics of the drug

Answer 6

-Taken orally

Distributed by the GI tract

Metabolised by the liver

Excreted by the kidneys/urine