Morphine

Question 1

Introduction to the drug

Answer 1

• Opioid analgesic used for severe pain relief

Question 2

Presentation

Answer 2

• Ampoules 10mg in 1ml

- Oral 10mg in 10ml

Question 3

Why would you prescribe this drug

Answer 3

• Severe pain

- MI

Question 4

Typical dose

Answer 4

• 2mg slowly every 5mins IV max dose 20mg

Question 5

Pharmacodynamics

Answer 5

• Opioids mediate their effect by agonising opioid receptors in the CNS. Stimulation of these receptors results in the opening of potassium channels which causes hyper polarisation and reduced excitability.
• Inhibits openinf of calcium channels
• Stimulation of MU receptors in pain relief
• Morphine affects the GI tract by decreasing Parasympathetic tone resulting in release of histamine

Question 6

Pharmacokinetics

Answer 6

• IV/IM/Oral absortion
• Widely Distributed
• Metabolised Hepactically
• Ecreted Renally

Question 7

Side Effects

Answer 7

• Respiratory depression
• Cardiovascular depression
• Nausea and Vomitting
• Drowsiness
• Pupillary constriction