Tenectaplase

Question 1

Introduction to the drug

Answer 1

Tenecteplase activates the fibronolytic system, inducing the breaking up of intravascular thrombi and emboli. In simple terms it helps the body produce a substance that dissolves unwanted blood clots.

Question 2

How is the drug administered and presented

Answer 2

• Vials 10,000 units for reconstitution with 10ml water for injection
• Vials 8,000 units for reconstitution with 8ml water for injection

Question 3

Why would you prescribe this drug

Answer 3

• Acute STMI elevation within 6hrs of the onset where PPCI is NOT available

Question 4

Dose when administered of this drug

Answer 4

• Administer a bolus injection of Heperin before Tenectaplase

<60kg = 6000units
60-69kg = 7000units
70-79kg = 8000units
80-89kg = 9000units
>90kg = 10000units

Question 5

What the drugs actions Pharmacodynamics

Answer 5

• Activates the fibrinolytic system, inducing the breaking up of a intravascular thrombi and emboli
• A relatively fibrin-selective plasminogen activator.

Question 6

What are the side effects of the drug

Answer 6

• Bleeding - Minor and major
• Arrthymias
• Anaphylaxis
• Hypotension

Question 7

Pharmacokinetics of the drug

Answer 7

• Vascular distribution
• Cleared by the liver.
• ## Excreted Renally