Diuretics

Question 1

Which diuretics inc K+ excretion?

Answer 1

Loop and thiazides because more Na+ delivered to collecting ducts

Question 2

Which diuretics create acidosis?

Answer 2

Carbonic anhydrase inhibitors (less bicarb reabsorbed)

K-sparing diuretics (block H+ secretion in collecting ducts)

Question 3

Which diuretics create alkalosis?

Answer 3

Loop and thiazides

1- because dec volume activates angio II which inc Na-H exchange in proximal tubule –> more bicarb reabsorbed

2- K+ loss leads to K leaving cells and H going into cells

3- in low K state H+ leaves at collecting ducts in place of K+

Question 4

Which diuretics inc Ca++ excretion?

Answer 4

Loop (less paracellular reabsorption in TAL)

Question 5

Which diuretics inc Ca++ reabsorption?

Answer 5

Thiazides