Oncogenes Flashcards by Sarah Hogan

Q

ALK

A

receptor tyrosine kinase

lung adenocarcinoma

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Q

BCR-Abl

A

tyrosine kinase

ALL CML

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Q

Bcl2

A

anti-apoptosis molecules (keeps cytochrome c in mitochondria)

Follicular and diffuse large B cell lymphoma

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Q

BRAF

A

serine/ threonine kinase

melanoma, NHL, papillary thyroid cancer

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Q

c - KIT

A

Cytokine receptor

GIST (GI stromal tumor)

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Q

c- MYC

A

Transcription factor

Burkitt lymphoma

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Q

HER2/neu

A

receptor tyrosine kinase

Breast and GI carcinoma

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Q

JAK2

A

tyrosine kinase

Chronic myeloproliferative disorders

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Q

KRAS

A

GTPase

Colon, lung, pancreatic cancer

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Q

MYCL1

A

Transcription factor

L - lung tumor

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Q

MYCN

A

Transcription factor

N - Neuroblastoma

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Q

RET

A

receptor tyrosine kinase

MEN2A and 2B, medullary thyroid cancer

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