Exam 3-2

Question 1

Karyopherins

Answer 1

facilitate nuclear transport through the NPC as mediators

• B - receptors
• A - adapters (cargo selective binding)

Question 2

nucleoporins

Answer 2

• building blocks of the NPC
• TF during development
• marker for cancer (244 and 88)

Question 3

nucleoporin N-terminus

Answer 3

XFXFG (FG repeats)

Question 4

nucleaporin C-terminus

Answer 4

heptad rep and coiled-coil conformation

Question 5

anesthetics are on the _____ part of the VG Na channels and have a greater effect on the axons that are _____ and ______. ex: _______

Answer 5

• intracellular
• smaller
• more active (i.e. pain receptors)
• lidocaine

Question 6

neurotoxins: extracellular blockers

Answer 6

• tetrodotoxin (puffer fish)

- saxitoxin (clams)

Question 7

neurotoxins: modulators of Na+ channel function

Answer 7

batrochotoxin (frogs)

Question 8

demyelinating diseases

Answer 8

MS (CNS) and Guillain-Barre syndrome (muscles)

Question 9

current propagation: effect of increased internal resistance

Answer 9

smaller spread

Question 10

current propagation: effect of increased membrane resistance

Answer 10

larger spread

Question 11

current propagation: effect of increased membrane capacitance

Answer 11

slower speed

Question 12

how to make the current propagation large and fast?

Answer 12

increase membrane resistance and decrease membrane capacitance

Question 13

myelin’s effect on current propagation

Answer 13

• increases membrane resistance and decreases membrane capacitance
• saltatory conduction
• faster and larger

Question 14

fastest to slowest reception (myelinated)

Answer 14

1. propioreception
2. touch reception
3. temerature/pain