Exam 3-9

Question 1

Dalfampridine

Answer 1

symptom management of MS, improve walking speeds

-K+ channel block to improve nerve function

Question 2

cholera sx

Answer 2

NVD and dehydration

Question 3

infectious dose of cholera

Answer 3

10^8

Question 4

CTX

Answer 4

alpha = active

• B= transporter (binds to GM1 gang receptor)
• a cleaved off and binds to G protein (continuous production of cAMP)

Question 5

CFTR in cholera

Answer 5

• Ca2+ and cAMP lead to Cl-secretion

- luminal

Question 6

Zot

Answer 6

• tight junction disassembly

- efflux of salt and water

Question 7

ace

Answer 7

binds to LDL receptor

Question 8

dynamin

Answer 8

pinches off neck of vesicle

Question 9

lipid rafts are regions high in

Answer 9

cholesterol and signaling molecules

Question 10

calveolin

Answer 10

make up calveoli (1, 2 and 3)

Question 11

______ domains of misfolded protein aggregate

Answer 11

hydrophobic

Question 12

hsp 70

Answer 12

binds exposed hydrophobic regions

uses ATP

Question 13

hsp 60

Answer 13

barrel-like, has isolation chamber

uses ATP

Question 14

ERp57

Answer 14

enzyme in ER for protein folding (S-S bond formation)