Exam 3-5 Flashcards by Lauren Oberle

Q

n-sec1

A

refolds syntaxin into active formation

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Q

NSF and alpha-SNAP

A

disassemble protein

NSF uses ATP hydrolysis

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Q

VAMP location

A

transport vesicle

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Q

SNAP location

A

target membrane

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Q

syntaxin location

A

target membrane

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Q

HIF is a ____ that is _____ dependent.

A

TF

oxygen

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Q

HIF-alpha is ______ by ___ and ___

A

hydroxylated by proline and aspraganine

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Q

VHL _____ normal HIF-alpha

A

ubiq

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Q

use _______ to target downstream GFs of HIF and ______ to target mTOR

A

S——-nib

______lumin

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Q

VHL is a

A

tumor suppressor

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Q

sign of VHL

A

hemangioloastomas

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Q

Type 1, 2A and 2B ____regulate HIF

A

up

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Q

Type 2C ____regulates HIF

A

down

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Q

most VHL are

A

clear cell sporadid

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Q

VHL chromosome and what else is on it

A

3p

also on this are BAP 1 and PRBM1

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