Exam 3-6

Question 1

HMGCoA is blocked by

Answer 1

statins

Question 2

SREBP

Answer 2

reg LDLR and synthesis proteins

Question 3

low cholesterol –>

Answer 3

SREBP TF releases

Question 4

SREBP is held in the ___ and cleaved in the ______

Answer 4

ER, golgi

Question 5

SCAP binds

Answer 5

SREBP and sterols

Question 6

insig binds

Answer 6

SCAP and increased cholesterol

Question 7

_______ carries SCAP to the golgi

Answer 7

COPII

Question 8

RIP proteins

Answer 8

S1P and S2P (need both to activate)

Question 9

cholesterol made of

Answer 9

polar OH group
steriod ring
hydrocarbon tail

Question 10

sphingolipids made of

Answer 10

• ceramide

- polar head group

Question 11

phospholipids made of

Answer 11

glycerol + 3P
polar head group
hydrocarbon tail

Question 12

erbB2

Answer 12

HER2/neu oncogene
found in breast cancers
can be reversed by Herceptin

Question 13

Gleevec

Answer 13

BRC-ABL
philadelphia chromosome
tyrosine kinase inhibitor

Question 14

Estrogen receptor is a(n)

Answer 14

oncogene