Which gates are open: before depolarization
inact gate
Which gates are open: depolarization
both Na
Which gates are open: repolarization
Na act and K
Which gates are open: refractory period
K
VG Na channels
S4 detects
positive feedback
Na>K?
- no = resting Vm
ENa =
60 mV
Ek =
-90 mV
resting Vm =
-70 mV
Na/K structures: voltage sensing
S4
Na/K structures: activation gate
S5-6
Na/K structures: inactivation gate
III - loop - IV
gating is controlled by
Vm
S4 has ___ or ____ every ____ residue
lysine
arginine
3rd
N-term is in the ______ and the C-term is in the ______
both in the cytoplasm