Gabapentin

Question 1

Gabapentin MOA

Answer 1

• mimics neurotransmitter GABA, but does not bind to GABA receptors and it does not appear to influence uptake of GABA
• involves it’s inhibition of alpha 2-delta subunit of voltage gated calcium channels

Question 2

Gabapentin SE

Answer 2

• CNS & respiratory depression
• hypersensitivity reactions
• neuropsychiatric effects
• suicidal ideation

Question 3

Gabapentin dosing

Answer 3

AUD: 300 mg QD THEN can target 600 mg TID

NEUROPATHIC PAIN: IMMEDIATE- 100-300mg 1-3 times daily ; target to 300-1200 Mg TID
Extended- 300 Mg ; target 900-3600 mg QD