Hydrocodone

Question 1

Hydrocodone MOA

Answer 1

Semisynthetic my opioid receptor agonist; can lead to histamine release

-can cause hypotension, orthostatic hypotension, and syncope

Question 2

Hydrocodone dosing

Answer 2

Not opioid tolerant pain management: single doses > 40 Mg or TDD 80 mg or more
Capsule: 10 mg q12 hrs; dose increases of 10mg q12 hrs every 3-7 days PRN
Tablets: 20 Mg QD; dose increases of 10-20 Mg every 3-5 days PRN