Methadone

Question 1

Methadone MOA

Answer 1

Potent mu opioid receptor agonist and used to treat opioid substance use disorder

-potential QTc prolongation

Question 2

Methadone dosing

Answer 2

OUD: 2.5-10 mg , 10-20 mg w/drinking problems , 20-30 mg w/ no signs of sedation/intoxication but symptoms of withdrawal MAX 30 mg initially

PAIN: initially 2.5-10 mg q8-12 hrs

*seen given QD and 110mg