Hydromorphone

Question 1

Hydromorphone MOA

Answer 1

Semisynthetic mu opioid receptor agonist that is a derivative of morphine

• hypotension, syncope, orthostatic hypotension
• histamine release

Question 2

Hydromorphone BBW

Answer 2

Respiratory depression

Question 3

Hydromorphone dosing

Answer 3

Acute pain: 0.2-0.5 mg IV q2-4hrs PRN
-usual dose 0.2-1mg q2-4 hrs PRN
Chronic pain: 0.2-0.4 mg IV q2-4 hrs PRN