Hydroxocabalamin

Question 1

Drug class

Answer 1

Antidote

Question 2

Pharmacology

Answer 2

An injectable form of V-B12 which is an antidote for cyanide toxicity. It binds with circulating & cellular cyanide to form cyanocobalamin which is then excreted in urine

Question 3

Metabolism

Answer 3

Excreted by kidneys

Question 4

Indications

Answer 4

Life-threatening cyanide toxicity (e.g shock, resp failure, seizure, ALOC or myocardial ischaemia

Question 5

Contraindications

Answer 5

Allergy and/or adverse drug reactions

Question 6

Precautions

Answer 6

• Hypertension (substantial > occur with admin)

* Pregnancy (ONLY use if benefits justifies potential risk to foetus)

Question 7

Side effects

Answer 7

• Anaphylaxis
• Chromaturia
• Erythema
• Rash (acne like)
• Hypertension
• Renal failure
• Headache
• Nausea and/vomiting
• Pain @ inj site

Question 8

Presentation

Answer 8

5g vial

Question 9

Onset

Duration

Answer 9

IV

Immediate

Several days

Question 10

Routes of administration

Answer 10

IV Infusion

Question 11

Adult dosages

Answer 11

IV INF

5g over 15min

Question 12

Special notes

Answer 12

• CONSULT - nonife threatening toxicity e.g headache, confusion, vomiting, dyspnoea, chest tightness