Ticagrelor

Question 1

Drug class

Answer 1

Antiplatelet

Question 2

Pharmacology

Answer 2

Is a reversibly binding, direct-acting adenosine diphosphate (ADP) receptor antagonist that inhibits platelet activation & aggregation

Question 3

Metabolism

Answer 3

Hepatic

Question 4

Indications

Answer 4

• Pts with STEMI (as defined by relevant QAS coronary artery reperfusion checklist) who have been accepted for pCI (as an adjunct medication to aspirin & heparin AND the receiving cardiologist is requesting administration

Question 5

Contraindications

Answer 5

• Allergy and/or adverse drug reaction
• Current use of ticagrelor or clopidogrel
• <18yrs
• Active bleeding (exclud. menses)
• Hx intercranial haemorrhage
• Hx hepatic impairment

Question 6

Precautions

Answer 6

• Concomitant meds known to induce bradycardia (e.g B-blockers, CCBs, digoxin)
• Symptomatic bradycardia (HR<60)

Question 7

Side effects

Answer 7

• Haemorrhage

* Bradycardia

Question 8

Presentation

Answer 8

• 90mg tablet

* 90mg ODT

Question 9

Route

Onset

Duration

Answer 9

PO

~30mins

7days (antiplatelet)

Question 10

Adult dosages

Answer 10

Pts with STEMI, accepted for pPCI (as adjunct to aspirin & heparin) AND cardiologist requests admin

• PO ≥18yrs 180mg